QANDLI DIABETNING XUSUSIY PATOLOGIYASI: ETIOLOGIYASI, PATOGENEZI VA MORFOLOGIK O‘ZGARISHLARI
Keywords:
Kalit so‘zlar:Diabetes mellitus, Insulin, giperglikemiya, glyukoza almashinuvi, insulin rezistentligi, endokrin tizim, oshqozon osti bezi, β-hujayralar, autoimmun jarayon, semizlik, angiopatiya, mikroangiopatiya, makroangiopatiya, diabetik nefropatiya, patogenez.Abstract
Annotatsiya:Qandli diabet zamonaviy tibbiyot va Patologiya fanida eng dolzarb muammolardan biri hisoblanadi. Ushbu kasallik insulin gormoni yetishmovchiligi yoki uning periferik to‘qimalarda biologik ta’sirining buzilishi natijasida rivojlanadigan surunkali metabolik patologiya bo‘lib, organizmda uglevod, yog‘ va oqsil almashinuvining chuqur buzilishi bilan kechadi. Kasallikning asosiy patogenetik omili Insulin funksiyasining yetarli bo‘lmasligi yoki uning retseptor darajasidagi rezistentligi hisoblanadi, bu esa glyukoza (shakar) almashinuvining izdan chiqishiga olib keladi. Natijada organizmda qonda shakar miqdorining oshishi holati rivojlanadi va bu uzoq davom etsa, ko‘plab a’zo va tizimlarda qaytarilmas morfologik o‘zgarishlar yuzaga keladi.
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